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研究发现老年COVID-19幸存者面临更高的阿尔茨海默病风险_我的网站

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一 | With a Tory leadership contest in full swing, former Chancellor Rishi Sunak has pledged to slash the basic rate of income tax by 20% by 2029 if he becomes UK prime minister, the largest such reduction in 30 years.,“What I’m putting to people today is a vision to deliver the biggest income tax cut since Margaret Thatcher’s government. It is a radical vision but also a realistic one, and there are some core principles that I’m simply not prepared to compromise on, whatever the prize,” Sunak emphasized.,Thatcher was Prime Minister of the UK from 1979 to 1990.,The ex-Chancellor also promised that if he prevails in the Tory leadership race, he will “never get taxes down in a way that just puts inflation up.” The 42-year-old added that he will “never make promises” he “can’t pay for” and he will “always be honest about the challenges” Britain faces.,Rishi Sunak Seeks to Crack Down on Foreign Lawbreakers, Increase Number of Deportations29 July, 09:11 GMT,“Because winning this leadership contest without levelling with people about what lies ahead would not only be dishonest – it would be an act of self-sabotage that condemns us to defeat at the next general election,” Sunak pointed out.,The Daily Mail cited an unnamed source from Foreign Secretary Liz Truss’s Tory leadership campaign as accusing Sunak of offering ‘jam tomorrow’.,“It’s welcome that Rishi has performed another U-turn on cutting tax, it’s only a shame he didn’t do this as chancellor when he repeatedly raised taxes. The public and Conservative Party members can see through these flip-flops,” the source argued.,This was echoed by Simon Clarke, chief secretary to the Treasury, who underscored that they “cannot afford to wait to help families, they need support now.” He made it clear that “Liz will cut taxes in seven weeks, not seven years.”,Sunak and Truss repeatedly locked horns over the tax issue during live TV debates last month, with the foreign secretary, in particular, accusing the former Chancellor of raising taxes “to the highest level in 70 years,” which is “not going to drive economic growth.”,Sunak claimed that the UK’s massive tax burden was the result of the unprecedented levels of government spending aimed at keeping the national economy afloat amid the coronavirus pandemic. Truss said that no other country was raising taxes, and accused Sunak of having no clear-cut plan for economic growth.,Meanwhile, voting ballots will start landing on doorsteps of Tory members starting Monday, with many of them expected to return the papers long before the September 2 deadline.,Sunak Unveils 10-Point Border Security Plan as Truss May Turn to Foreign Policy in Fight for PM Seat24 July, 06:12 GMT,Sunak and Truss are now two remaining candidates in the race to replace Boris Johnson as Conservative Party leader and prime minister. Both secured their places in the final two in July, when Trade Minister Penny Mordaunt was knocked out in the fifth round of voting by Conservative MPs.,The two contenders are set to spend the next few weeks campaigning for the votes of about 180,000 Conservative Party members around the country, who will vote by postal or online ballot. The winner of the party leadership race, who will be announced on September 5th, is due to automatically become UK prime minister.。

二 | 来自凯斯西储大学医学院的Pamela Davis是这项新研究的共同作者，他解释说：“人们对阿尔茨海默病的发展因素知之甚少，但有两点被认为很重要，那就是先前的感染，特别是病毒感染，以及炎症。由于感染SARS-CoV-2与包括炎症在内的中枢神经系统异常有关，我们想测试一下，即使在短期内，COVID是否会导致诊断的增加。”该研究分析了6245282名65岁以上美国人的健康记录。在15个月的时间里，这些受试者中有40多万人记录了COVID-19的感染。在接下来的360天里，与未被感染的人相比，这些COVID的幸存者被诊断为阿尔茨海默病的可能性增加了69%。

三 | 女性和85岁以上的人患阿尔茨海默病的风险增加幅度最大。尽管这种阿尔茨海默病风险的增加听起来令人震惊，但重要的是要把它放在一个更广泛的背景下。研究人员明确指出，在COVID-19之后，65岁以上人群的总体阿尔茨海默病风险仅从0.35%增加到0.68%。因此，虽然这在技术上意味着一个人在感染COVID之后的一年中被诊断为阿尔茨海默病的风险增加了一倍，但这也意味着65岁以上的人仍然只面临非常低的绝对患病风险。此外，研究人员谨慎地指出，目前还不清楚这种病毒是否引发了阿尔茨海默病的新发展，或者只是加速了先前存在的神经变性的进展。考虑到阿尔茨海默病是一种在症状出现之前缓慢发展数年，甚至数十年的疾病，这些新的阿尔茨海默病病例不太可能完全由新冠病毒引起。尽管如此， Davis确实强调，即使是疾病进展的加速也可能在不久的将来导致一波阿尔茨海默病病例。

四 | 而且这还是在我们了解COVID-19可能带来的长期神经系统影响之前。

五 | Davis补充说：“如果这种新诊断的阿尔茨海默病的增加能够持续下去，那么目前没有治愈的疾病的患者浪潮将是巨大的，并可能进一步使我们的长期护理资源紧张。阿尔茨海默病是一种严重的、具有挑战性的疾病，我们认为通过减少一般的风险因素，如高血压、心脏病、肥胖和久坐的生活方式，我们已经扭转了这种疾病的一些趋势。现在，美国有这么多人感染了COVID，而COVID的长期后果仍在显现。继续监测这种疾病对未来残疾的影响是很重要的。

六 | ”之前的研究已经在病毒感染和神经退行性疾病之间建立了一个相对有力的联系。而且研究人员自该大流行病开始以来一直在警告，我们可能会在未来十年内看到帕金森和阿尔茨海默病的病例激增。在今年早些时候发布了另一项研究，将COVID-19与神经系统疾病的风险增加联系起来之后，英国阿尔茨海默病研究中心的Sara Imarsio明确强调，现在了解这种大流行病的长期影响还为时尚早。而这些初步研究只能强调病毒感染可能会加速那些已经易感的人的疾病发展。“像阿尔茨海默病这样的疾病在大脑中发展了很多年，而COVID-19自2020年初才出现在欧洲，”今年早些时候，Imarsio解释说。“可能是处于阿尔茨海默病非常早期阶段的人更容易染上像COVID-19这样的疾病。